In the UK (and other countries outside of the U.S) 'TBBT' translates very well

The fan base (including me) not only 'get it' - but love the show very much

http://www.radiotimes.com/programme/n85 ... ang-theory
I think it's success is because interest in sci fi, superheros, science; not to mention social awkwardness (especially Sheldon's obvious autistic behaviour - Parsons has acknowledged this in earlier interviews) are all something that aren't an American thing; but a world wide thing! When you watch it, it could be set anywhere. I have met guys like that from all nationalities

I would say something like Mike and Molly fits your description of a show made primarily for an American audience, but even so, many people still love that too!
Matt